Charles Ndereyehe Ntahontuye comes from Cyabingo commune, Rwanda.
According to accusations presented by the Rwandan authorities, in 1992, together with other Rwandan intellectuals, he allegedly created the Circle of Progressive Republicans (CPR). The CPR has been considered extremist due to its incitement to commit genocide against the Tutsi. The same year, Ndereyehe allegedly left the presidential party in order to contribute to the establishment of the Radical Hutu Coalition for the Defense of the Republic, which would later play a crucial role in the genocide.
In 1993, he became director of the Rwandan Institute for Agronomic Studies (RIAS)). In this capacity, he allegedly ousted from the leadership positions its members who did not share his anti-Tutsi convictions. The Rwandan authorities also suspect him of supervising the recruitment and training of a militia in March 1993, intended to commit the genocide in 1994.
He is suspected by Rwanda of leading the meetings at RIAS in April 1994 in order to prepare for the upcoming genocide and to plan total extermination of Tutsis at RIAS and vicinity. The plan would have been implemented at the end of the same month: on 26 April 1994, more than 300 people were killed during the massacre. In May 1994, he allegedly provided significant financial support for the perpetrators of the genocide by allocating part of the RIAS budget to operations against Tutsis and as a reward for those committing crimes against Tutsis.
In 1994, Ndereyehe fled Rwanda for the Democratic Republic of Congo (DRC), where he reportedly created the Republican Assembly for Rwandan Democracy (RDR).
Currently, he lives in the Netherlands where he continues his political activities. He is allegedly one of the leaders of the unregistered United Democratic Forces (FDU-Inkigi), which forms an alliance with the RDR, which has links with the Democratic Forces for the Liberation of Rwanda (FDLR).