Pierre Kayondo was reportedly a shareholder of the Radio Television Les Milles Collines – a radio station that played a fundamental role in the genocide, inciting massacres and spreading hatred against the Tutsi and moderate Hutus.
He was reportedly a member of the Mouvement Republicain National pour la Démocratie et le Développement (National Republican Movement for Democracy and Development), which had close ties to the Interahamwe militia.
He is also alleged to have taken part personally in the massacres.
On 22 September 2021, the Collectif des Parties Civiles pour le Rwanda launched a complaint against Kayondo for his alleged involvement in the 1994 genocide in Rwanda.
On 18 October 2021, the French prosecuting authorities opened an investigation against him for his involvement in crimes of genocide and crimes against humanity allegedly committed between April and July 2014.